Effect of curcumin on angiogenesis of rats with DEN-induced hepatocellular carcinoma under hypoxia
10.3872/j.issn.1007-385x.2018.02.005
- VernacularTitle:姜黄素对化学诱导大鼠肝癌缺氧模型血管生成的影响
- Author:
YANG Chuanyu
1
,
2
;
ZENG Rongyao
3
;
LIU Rongliang
4
;
WANG Xiaowen
4
;
KE Enming
4
;
LIU Jing
4
Author Information
1. 1. Graduate School of Fujian Medical University, Fuzhou 353000, Fujian, China
2. 3. Department of General Surgery, the 175th Hospital of PLA, Zhangzhou 363000, Fujian, China
3. 2. Department of Emergency, SecondAffiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian, China
4. 3. Department of General Surgery, the 175th Hospital of PLA, Zhangzhou 363000, Fujian, China
- Publication Type:Journal Article
- Keywords:
curcumin;
rat;
hepatocellular carcinoma;
hypoxia;
angiogenesis
- From:
Chinese Journal of Cancer Biotherapy
2018;25(2):137-141
- CountryChina
- Language:Chinese
-
Abstract:
[Abstract] Objective: To investigate the effect of curcumin on angiogenesis in rats with DEN (diethylnitrosamine)-induced HCC (hepatocellular carcinoma) under hypoxia. Methods: Rat HCC was induced by DEN, and its hepatic hypoxia model was established by ligating hepatic artery. The rats with established HCC model were randomly divided into four groups according to digital table method: lipiodol embolization group (group A), lipiodol combined with curcumin embolization group (group B), lipiodol combined with peripheral liver capsule group (group C), lipiodol combined with curcumin and peripheral liver capsule group (group D), with 10 rats in each group. VEGF expression in HCC cells and tissues, microvessel density (MVD), and median survival time (MST) of rats in each group were compared. Results: VEGF protein expression and microvessel density in group B, D were significantly lower than those in A group ( P <0.01), while those in C group had no significant difference compared with group A ( P >0.05). MST in group B, C and D was significantly longer than that in group A ( P <0.05), and the MST in group D was higher than that in group B and C ( P <0.05). Conclusion: Curcumin can inhibit tumor angiogenesis and decrease VEGF expression and MVD in HCC rats under hypoxia, thus further prolong the survival time of the rats.
- Full text:20180205.pdf
