Elevated serum rheumatoid factor, anti-citrullinated protein antibodies and active rheumatoid arthritis disease are not associated with chronic periodontitis
- Author:
Mohd Jazman Che Rahim
1
Author Information
1. Department of Internal Medicine, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
- Collective Name:Wan Majdiah Wan Mohamad; Norkhafizah Saddki; Haslina Taib; Wan Zuraida Wan Abhamid; Kah Keng Wong; Wan Syamimee Wan Ghazali
- Publication Type:Journal Article
- Keywords:
Rheumatoid arthritis;
chronic periodontitis;
rheumatoid factor;
anti-citrullinated protein antibodies;
28-joint Disease Activity Score
- From:The Malaysian Journal of Pathology
2019;41(3):267-272
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease of the joints
with the involvement of other systems. Previous studies have demonstrated its association with
chronic periodontitis (CP), a chronic inflammatory disease of tooth-supporting tissues. Positive
rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) in RA patients have been
found to be associated with CP. The aim of this study is to determine the prevalence of CP in RA
patients, and to investigate the association of ACPA, RF status and RA disease activity with CP and
non-CP RA patients. Materials and Methods: A comparative cross-sectional study involving 98 RA
patients was conducted at Hospital Universiti Sains Malaysia, Kubang Kerian, Malaysia. Clinical oral
examination was carried out to determine the CP status of RA patients. RF, ACPA and erythrocyte
sedimentation rate (ESR) were measured, and the 28-joint Disease Activity Score (DAS-28) was
assessed. Results: Forty-five patients (45.9%) were found to have CP (95% CI: 0.36-0.56). No
significant difference was observed in the prevalence of positive RF (p=0.989) or ACPA (p=0.431)
in CP and non-CP RA patients. There was also no significant association between active RA disease
(DAS-28 score ≥3.2) and RF positivity in CP (p=0.927) and non-CP (p=0.431) RA patients as well
as ACPA positivity in CP (p=0.780) and non-CP (p=0.611) RA patients. Conclusion: In our cohort
of RA patients, we did not find significant associations between elevated RF, ACPA, or active RA
disease with the presence of CP. There were also no significant associations between elevated RF
or ACPA with active RA disease.
- Full text:5.2019my01021.pdf
