Diagnostic performance of anti-RA33 antibody as a serological marker for rheumatoid arthritis
- Author:
Syed Mohamad Syed Mohamed Suhail
1
Author Information
1. Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia.
- Collective Name:Ideris Nur Atiqah; Zainal Abidin Nur Salimi Zakirah; Zainal Lailatul Syazwani; Wyzle Well Batis; Ezura Madiana Md Monoto; Asrul Abdul Wahab; Mohamed Said Mohd Shahrir
- Publication Type:Journal Article
- Keywords:
anti-RA33 antibody;
rheumatoid arthritis;
rheumatoid factor
- From:The Malaysian Journal of Pathology
2019;41(3):259-265
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Rheumatoid arthritis is diagnosed based on the 2010 Rheumatoid Arthritis Classification
Criteria whereby rheumatoid factor and anti-citrullinated protein antibody are the serological markers
included in these criteria. Anti-RA33 antibody has the potential to provide additional diagnostic
value in rheumatoid arthritis. The aim of this study is to determine the diagnostic performance of
anti-RA33 antibody as a serological marker for rheumatoid arthritis. Material and methods: Thirtyfour patients with rheumatoid arthritis and 34 non-rheumatoid arthritis individuals were included
in this cross-sectional study. Anti-RA33 antibody and rheumatoid factor were performed on all
samples. Results: The sensitivity, specificity, positive and negative predictive value for anti-RA33
antibody and rheumatoid factor were 41.1%, 97.1%, 93.3%, 62.3% and 64.7%, 79.4%, 75.9%, 69.2%
respectively. The overall sensitivity and specificity if either anti-RA33 antibody or rheumatoid factor
are positive were 79.4% and 76.47% respectively. Conclusion: Anti-RA33 antibody showed good
specificity and positive predictive value and could be considered as a potential serological marker
for rheumatoid arthritis diagnosis.
- Full text:5.2019my01020.pdf
