Analysis for polymorphism of MTHFR C677T gene in Han population in Beijing
10.13602/j.cnki.jcls.2019.02.19
- VernacularTitle:北京地区汉族人群MTHFR C677T基因多态性分析
- Author:
Dandan LI
1
,
2
;
Ali YE
1
,
2
;
Yong GAN
1
,
2
;
Pengchang LI
1
,
2
;
Jie WU
1
,
2
;
Ling QIU
1
,
2
Author Information
1. Peking Union Medical College &
2. Chinese Academy of Medical Science, Department of Clinical Laboratory, Peking Union Medical College Hospital
- Publication Type:Journal Article
- Keywords:
Han nationality;
MTHFR;
genetic polymorphism;
Beijing
- From:
Chinese Journal of Clinical Laboratory Science
2019;37(2):156-160
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the distribution characteristics of MTHFR gene polymorphism of Chinese Han population in Beijing, and analyze the differences of distribution of MTHFR gene polymorphism between Beijing area and the other parts of northern China.
Methods:MTHFR C677T gene was detected by PCR-gold magnetic particles chromatography. The distribution characteristics of MTHFR gene polymorphism of 3 945 healthy subjects from September 2014 to May 2018 detected in Peking Union Medical College Hospital were analyzed retrospectively. The distribution of MTHFR gene polymorphism in Chinese Han population in Beijing area was compared with the Han population of the other area from northern China by reviewing domestic and foreign literature databases.
Results:The frequencies of CC, CT and TT genotype of MTHFR C677T gene in the male population undergoing physical examination in Beijing were 23.3%, 50.5% and 26.2%, respectively, and the frequencies of C and T allele frequencies were 48.6% and 51.4%, respectively. The frequencies of CC, CT and TT genotype of MTHFR C677T gene in the female population were 22.7%, 49.4% and 27.9%, respectively, and the C and T allele frequencies were 47.4% and 52.6%, respectively. There was no difference in genotype frequency and allele freaaency between male and femal (P＞0.05). The frequencies of CC, CT and TT genotypes and allele frequencies of MTHFR C677T gene in the population of Beijing area were significantly different from those of Heilongjiang, Jilin, Hebei, Shandong and Henan provinces (P＜0.01).
Conclusion:There was no significant difference of polymorphism distribution of MTHFR C677T gene between male and female populations in Beijing. The distinct distribution characteristics of MTHFR gene in Beijing area should be presented.
