Screening of lncRNAs in female non-smoking lung cancer patients based on TCGA data
10.13602/j.cnki.jcls.2019.02.17
- VernacularTitle:基于TCGA数据的女性不吸烟肺癌患者相关lncRNAs的筛选
- Author:
Lihua XIAO
1
;
Chun LI
1
;
Wenming ZENG
2
;
Na LI
2
;
Huiming YIN
3
Author Information
1. Department of Clinical Laboratory, the Second Hospital Affiliated to University of South China
2. Department of Pathology, the First Affiliated Hospital of Hunan University of Medicine
3. Pepartment of Respiratory Medicine, the First Affiliated Hospital of Hunan University of Medicine
- Publication Type:Journal Article
- Keywords:
female non-smoking lung cancer;
TCGA data;
long non-coding RNA
- From:
Chinese Journal of Clinical Laboratory Science
2019;37(2):148-151
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To screen the differentially expressed long non-coding RNAs(lncRNAs) by analyzing the related gene sequencing data of female non-smoking lung cancer patients in the database of The Cancer Genome Atlas (TCGA).
Methods:The gene expression data and the corresponding clinical information of female non-smoking lung cancer patients were downloaded from the TCGA database. Then, the data were processed, integrated and analyzed with the R software package, and the differentially expressed genes were screened out. The prognosis was analyzed by the Survival package.
Results:A total of 354 differentially expressed lncRNAs associated with female non-smoking lung cancer were obtained, of which 45 were down-regulated and 309 were up-regulated in tumor tissues. The prognosis analysis showed that the expression level of LINC01863 was positively correlated with the prognosis of female non-smoking lung cancer patients (P＜0.05), and that the expression levels of LINC02487, LINC01419 and DSCAM-AS1 were negatively correlated with the prognosis of female non-smoking lung cancer patients (P＜0.05).
Conclusion:The re-analysis on the high-throughput sequencing data in TCGA database obtains a large number of lncRNAs related to the development of female non-smoking lung cancer, which provides the potential new targets for the diagnosis and prognosis assessment of female non-smoking lung cancer.
- Full text:肖梨花 主编审阅稿 20181548.docx
