Correlation analysis of single nucleotide polymorphisms in autophage-related 5 ( ATG[STHZ]5[STBZ] ) gene promoter with acute myocardial infarction
10.13602/j.cnki.jcls.2019.02.02
- VernacularTitle:ATG5基因启动子区域单核苷酸多态性与急性心肌梗死的相关性分析
- Author:
Yexin ZHANG
1
;
Ruchao MA
1
;
Wentao YANG
2
,
3
;
Shuchao PANG
4
;
Yinghua CUI
4
;
Bo YAN
1
,
5
,
6
Author Information
1. Department of Cardiology, Cheeloo Medical College, Shandong University
2. Department of Cardiology, Dongying People&prime
3. s Hospital
4. Central Laboratory, Affiliated Hospital of Jining Medical University
5. Central Laboratory, Affiliated Hospital of Jining Medical University
6. Clinical College of Jining Medical University
- Publication Type:Journal Article
- Keywords:
myocardial infarction;
autophagy;
autophagy-related 5;
single nucleotide polymorphism;
haplotype
- From:
Chinese Journal of Clinical Laboratory Science
2019;37(2):87-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation of single nucleotide polymorphisms (SNPs) in autophage-related 5 ( ATG5 ) gene promoter with acute myocardial infarction (AMI).
Methods:The SNPs of ATG5 gene promoter were detected by polymerase chain reaction (PCR) and Sanger sequencing. The typing and correlation of SNPs in 378 AMI patients and 374 healthy controls were analyzed by Chi-square test, Logistic regression analysis and haplotype analysis.
Results:Two SNPs of ATG5 gene promoter, rs506027 (OR=1.4, 95% CI \[0.6-3.0\], P=0.411) and rs510432 (OR=1.6, 95% CI \[0.7-3.4\], P=0.275), were found. They didn′t increase the susceptibility of AMI, and the haplotype associated with AMI was not found in the two SNPs.
Conclusion:The polymorphism of ATG5 gene promoter isn′t associated with the susceptibility of AMI.
- Full text:张业欣 排版稿 20181553.docx
