Higher preoperative platelet-to-lymphocyte ratio is a poor prognostic marker for the early stage malignant melanoma patients
10.3872/j.issn.1007-385X.2018.05.012
- VernacularTitle:术前高血小板和淋巴细胞比值是早期恶性黑色素瘤患者的不良预后因素
- Author:
CAO Yanjiao
1
;
ZHANG Weihong
1
;
DU Weijiao
1
;
WANG Xuemin
1
;
CAO Shui
1
Author Information
1. （Department of Biotherapy, Cancer Hospital of Tianjin Medical University, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Clinical Research Center for Malignant Cancer of Tianjin City, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin City, Tianjin 300060, China
- Publication Type:Journal Article
- Keywords:
malignant melanoma (MM);
platelet-to-lymphocyte ratio（PLR）;
prognosis
- From:
Chinese Journal of Cancer Biotherapy
2018;25(5):509-514
- CountryChina
- Language:Chinese
-
Abstract:
[Abstract] Objective: To explore the relationship between the preoperative blood indicators (platelets, monocytes, neutrophils-to-lymphocyte ratio) and clinicopathological characters and the prognosis of the early stage malignant melanoma（MM）patients. Methods: Clinicopathological data of 120 cases of stage I-III MM patients, who received initial treatment and radical operation in the Cancer Hospital of Tianjin Medical University from January 2007 to May 2012, were obtained for this study. The correlations between parameters of PLR (platelet-to-lymphocyte ratio), LMR (lymphocyte-to-monocyte ratio), NLR (neutrophil-to-lymphocyte ratio), hemoglobin, neutrophils, lymphocytes, monocytes, eosinophils, basophils, platelets, lactate dehydrogenase, age, stage as well as ulcer and the prognosis of the patients were evaluated. Results: Patients whose tumor with ulceration have higher NLR and basophilic granulocyte (all P< 0.05）. Univariate analysis showed that NLR, PLR, LMR, neutrophil, lymphocyte, monocyte, lactic dehydrogenase, age, stage and ulceration were the risk factors of poor 5-year overall survival (P<0.05). The multivariate analysis identified PLR（HR=4.206， 95%CI:1.65410.696， P<0.01），stage（HR=7.670， 95%CI:3.977-14.795， P<0.01）and ulceration（HR=1.931， 95%CI:1.029-3.623， P<0.05）as independent risk factors for the prognosis of the MM patients. Conclusion: Higher preoperative PLR can be used as a predictive factor for poor prognosis of the early stage MM patients.
- Full text:20180512.pdf
