Relationship between interleukin-6 -572 gene polymorphism and aggressive periodontitis in Chinese
10.12016/j.issn.2096-1456.2017.11.008
- Author:
LI Jing
1
;
LIANG Jing
1
;
XU Ting
1
;
TAN Fengqing
1
;
LIU Juan
2
;
ZENG Xiongqun
2
Author Information
1. Guangzhou Haizhuqu District Stomatological Hospital
2. The Stomatological Hospital, Southern Medical University
- Publication Type:Journal Article
- Keywords:
Interleukin-6;
Chronic periodontitis;
Aggressive periodontitis;
Single nucleotide polymorphism;
Allele
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2017;25(11):718-722
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between interleukin-6 -572 gene polymorphism and aggressive periodontitis.
Methods :A case-control study involved 83 patients with aggressive periodontitis (AgP) and 69 health controls was held, and the genotype and allele distributions of interleukin-6 -572 gene polymorphism were analyzed by PCR-RFLP.
Results :There was statistically significant differences in the genotype distribution by the chi-square test in the two groups (χ2 = 13.710, P=0.001). The distribution of allele frequencies in AgP group was statistically different (χ2=13.213, P < 0.001) from the healthy control group, and the OR for the G allele is 2.988 (95%CI: 1.634-5.465) when compared with the C allele.
Conclusion:IL-6 -572 gene polymorphism is associated with the susceptibility to AgP in Chinese Han population of Guangdong, and the IL-6 -572 G allele might be a risk factor of the genetic susceptibility to AgP.
- Full text:IL-6 -572基因多态性与侵袭性牙周炎易感性的相关性研究.pdf
