Analysis of the impact of maternal hepatitis B virus infection on vaccination effect of the offspring
10.3969/j.issn.1006-2483.2020.02.034
- VernacularTitle:母亲乙肝病毒感染状况对其子代疫苗接种效果影响的分析
- Author:
Benke LI
1
;
Min JI
1
;
Xu ZHAO
1
Author Information
1. Intervention Department of Dalian Sixth People's Hospital, Dalian, Liaoning 116031, China
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus infection;
Offspring;
Vaccination;
Influencing factors
- From:
Journal of Public Health and Preventive Medicine
2020;31(2):138-140
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the impact of maternal hepatitis B (HBV) virus infection status on the vaccination effect of the offspring. Methods Eighty-six pairs of HBV-infected mothers and newborns who were treated in Dalian Sixth People's Hospital from 2017 to 2019 were selected as the research subjects. According to the strength of the hepatitis B vaccine response, all patients were divided into two groups, the observation group (none or weak response) and the control group (strong response). Hepatitis B virus infection was compared between the mothers of the two groups, and multivariate logistic regression was used to analyze the influencing factors of vaccination effect of the offspring. Results The positive rate of HBV DNA in mothers of the observation group was higher than that in the control group. HBV DNA was mainly at high load and HBeAg was at low level. The HBV DNA of the control group was mainly at low load, while the distribution of HBeAg was close. The difference was statistically significant (P < 0.05). HBV infection pattern in the observation group was "HBsAg(+), HBeAg(+), anti-HBc(+)" in 14 cases (51.85%), "HBsAg(+), anti-HBe(+), anti- HBc(+)" in 11 cases (40.74%) , while there were 27 cases (45.76%), 25 cases (42.37%), and 7 cases (11.86%), respectively, in the control group. The difference was statistically significant (P<0.05). Multivariate logisitic regression analysis showed that HBV DNA positivity, HBV DNA high load, HBeAg positivity, and low HBeAg levels were risk factors for weak response of the offspring vaccination. Conclusion HBV DNA positivity, high HBV DNA load, HBeAg positivity, and low HBeAg levels in HBV-infected mothers were risk factors for weak response of the offspring to vaccines, which should be paid attention to in clinic.
