The Radiotherapy Result of the Nasopharyngeal Carcinoma.
- Author:
Charn Il PARK
1
;
Kyoung Hwan KOH
;
Chong Sun KIM
;
Noe Kyeong KIM
Author Information
1. Department of Radiology, College of Medicine, Seoul National University, Korea.
- Publication Type:Original Article
- MeSH:
Carcinoma;
Carcinoma, Squamous Cell;
Cranial Nerves;
Diagnosis;
Drug Therapy;
Humans;
Lymph Nodes;
Neck;
Neoplasm Metastasis;
Radiation Oncology;
Radiotherapy*;
Recurrence;
Retreatment;
Seoul;
Survival Rate;
Treatment Failure
- From:Journal of the Korean Society for Therapeutic Radiology
1983;1(1):85-94
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A total of 47 patients with a diagnosis of nasopharyngeal carcinoma was treated in Department of Therapeutic Radiology, Seoul National University Hospital during last 4 years. Of the 47 patients, 23(49%) had undifferentiated carcinoma, 20(43%) had squamous cell carcinoma, while 4(8%) had lymphoepithelioma. Most of the patients(71%) has Stage IV disease, cervical lymph node metastases were found in 36(77%) and distant metastasis was found in 1 at the time of diagnosis. Complete response rate after radiotherapy for 47 patients of nasopharyngeal carcinoma was 85.1%. The overall actuarial 3 year survival rates was 0.718 and the disease free actuarial 3 year survival rates was 0.468. Nodal involvement and symptom duration were statistically significiant influencing factors for actuarial survival rate. Treatment failures were found in 20 patients (42.6%), local recurrence only in 6(30%), local and neck recurrence in 3(15%), local recurrence with metastasis in 4(20%) and distant metastasis only in 7(35%). Local failures were more frequent in the patients with cranial nerve symptoms (P=0.032). Distant metastases were more frequent with T4 lesions (P=0.047), and with nodal involvement (P<0.01). Retreatment after the tumor recurrence was chemotherapy and/or radiotherapy, two patients refreated for local recurrence were alive without evidence of disease for more than 19 and 44 months after retreatment.
