Predictive value of baseline CD4+ Cell Counts and CD4/CD8 ratio in immune reconstitution in HIV/AIDS patients receiving highly effective antiretroviral therapy
- VernacularTitle:HAART治疗AIDS患者基线CD4+细胞水平对免疫重建效果的预测价值
- Author:
Ling YU
1
;
Jun SUI
1
;
Jing HUANG
1
Author Information
- Publication Type:Journal Article
- Keywords: HIV/AIDS; HAART; Immune reconstitution; CD4+T
- From: Journal of Public Health and Preventive Medicine 2020;31(2):58-61
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the predictive value of baseline CD4+ cell counts and CD4/CD8 ratio in immune reconstitution among HIV/AIDS patients receiving highly effective antiretroviral therapy (HAART). Methods A total of 90 HIV/AIDS patients who had received over 24 months of HAART regimen and had viral road <50 copies/ml were enrolled in this study. The patients were subgrouped into immunological non-responders (INRs) (<200 cells/μl), immunological inadequate responders (IIRs) (200~500 cells/μl) and immunological responders (IRs) (>500 cells/μl) according to the CD4 cell counts after two-year HAART regimen. The characteristics and dynamic CD4+ cell counts among the three groups were compared, and the factors of immune reconstitution were analyzed. Results The CD4+ cell counts in the immunological responders (IRs) were significantly higher than those in the immunological non-responders (INRs) and immunological inadequate responders (IIRs) (P<0.001). The analysis of area under the ROC curve reveled that the number of CD4+ cells reached the highest predictive value at 1 year of HAART. Conclusion Our findings suggested that early initiation of HAART could reduce the failure of immune reconstitution. The combination of baseline CD4+ cell counts and baseline CD4/CD8 ratio may serve as a valid predictor of immune reconstitution prognosis after HAART.
