Expression of lncRNA DGCR5 in esophageal squamous cell carcinoma tissues and its clinical significance
10.3872/j.issn.1007-385x.2020.04.012
- VernacularTitle:lncRNADGCR5在食管鳞状细胞癌组织中的表达及其临床意义
- Author:
DUAN Yuqing
1
;
WANG Mengjie
1
;
WANG Hongyan
2
;
WANG Yu
1
;
SANG Meixiang
3
;
LIU Lihua
1
Author Information
1. a. Department of Tumor Immunotherapy
2. b. Department of Chest Surgery
3. c. Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050035, Hebei, China
- Publication Type:Journal Article
- Keywords:
esophageal squamous cell carcinoma (ESCC);
long non-coding RNA (lncRNA);
DiGeorge syndrome critical region gene 5 (DGCR5);
TCGAdatabase;
survival analysis
- From:
Chinese Journal of Cancer Biotherapy
2020;27(4):416-419
- CountryChina
- Language:Chinese
-
Abstract:
[Abstract] Objective: To investigate the expression of long non-coding RNA (lncRNA) DiGeorge syndrome critical region gene 5 (DGCR5) in esophageal squamous cell carcinoma (ESCC) tissues, and to analyze its relationship with clinicopathological features and prognosis of ESCC patients. Methods: The expression of DGCR5 in ESCC data set from TCGA database was analyzed by bioinformatics method. Sixty pairs of ESCC tissues and para-cancerous tissues resected at the Fourth Hospital of Hebei Medical University from August 2016 to March 2017 were collected for this study. The expression of DGCR5 in ESCC tissues was detected by qPCR. The correlation between the expression of DGCR5 and the clinicopathological features and prognosis of ESCC patients was analyzed. Results: TCGAdatabase analysis showed that the expression of DGCR5 in ESCC tissues was significantly higher than that in normal esophageal tissues (P<0.01). The expression of DGCR5 in ESCC tissues was significantly higher than that in para-cancerous tissues (P<0.01). The expression level of DGCR5 was significantly correlated with TNM staging and lymph node metastasis in ESCC patients (all P<0.05). Kaplan-Meier univariate analysis showed that the 2-year survival rate of ESCC patients with high DGCR5 expression was significantly lower than that of patients with low expression (P<0.05). Conclusion: DGCR5 is highly expressed in ESCC tissues and is closely related to TNM staging, lymph node metastasis and poor prognosis, which may serve as a molecular marker for early diagnosis and prognosis prediction of ESCC.
- Full text:20200412.pdf
