Research progress of epigenetic regulation of vascular diseases
- VernacularTitle:血管疾病的表观遗传学研究进展
- Author:
LI Dongze
1
,
2
;
LI Fanghui
3
;
ZENG Rui
3
;
CAO Yu
1
,
2
;
WAN Zhi
1
,
2
Author Information
1. 1. Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China
2. 2. Disaster Medical Center, Sichuan University, Chengdu, 610041, P.R.China
3. Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China
- Publication Type:Journal Article
- Keywords:
Vascular diseases;
TET methylcytosine dioxygenase 2;
epigenetics
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2020;27(04):471-475
- CountryChina
- Language:Chinese
-
Abstract:
Epigenetics refers to heritable changes in gene expression independent of DNA nucleotide sequence itself, and the main mechanisms include DNA methylation, histone modifications, noncoding RNAs, and so on. Vascular disease is a chronic disease regulated by the interaction between environmental and genetic factors. In recent years, more and more studies have confirmed that epigenetic regulation plays an important role in the occurrence and development of vascular diseases. This article reviews recent advances in epigenetics in vascular disease.
