Correlation between blood transfusion and postoperative acute kidney injury after heart transplantation
- VernacularTitle:输血与心脏移植术后急性肾损伤相关性研究
- Author:
ZENG Xiaodong
1
,
2
;
LEI Liming
1
,
2
;
XIONG Weiping
1
,
2
;
WU Yijin
1
,
2
;
HUANG Jingsong
1
,
2
;
ZHUANG Jian
1
,
2
;
CHEN Jimei
1
,
2
;
ZHU Weizhong
1
,
2
;
LUO Dandong
1
,
2
Author Information
1. Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangdong Provincial People&rsquo
2. s Hospital, Guangzhou, 510080, P.R.China
- Publication Type:Journal Article
- Keywords:
Heart transplantation;
blood transfusion;
acute kidney injury;
renal replacement therapy
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2020;27(04):426-430
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between perioperative blood transfusion and acute kidney injury (AKI) after heart transplantation. Methods A retrospective study was performed on 67 patients who underwent heart transplantation in the Department of Cardiac Surgery, Guangdong Provincial People's Hospital from January 2016 to December 2018, and finally 63 patients were included according to the exclusion criteria. There were 53 males and 10 females with an average age of 44.3±12.9 years. Twenty patients who adopted continuous renal replacement therapy (CRRT) after heart transplantation were divided into a RT group and the other 43 patients who did not use CRRT were divided into a non-RT group. Baseline characteristics, perioperative blood transfusion data and clinical prognosis were compared between the two groups. Results The preoperative baseline characteristics of the two groups were basically the same. There were significant differences in perioperative infusion of red blood cells and plasma, postoperative 24 h bleeding and re-exploration (P<0.05) between the two groups. The area under the receiver operating characteristic (ROC) curve was 0.923 (95%CI 0.852 to 0.995, P<0.001). The ROC curve showed that perioperative infusion of red blood cells more than 18 mL/kg would increase the incidence of AKI after heart transplantation. Conclusion Perioperative blood transfusion is closely related to AKI after heart transplantation. The more blood transfusion is in clinics, the higher incidence of renal injury is and the worse prognosis is. It is suggested that various blood-saving measures can be carried out.
