Advances of near-infrared fluorescent probes for detection of Alzheimer′s disease
10.11665/j.issn.1000-5048.20200203
- VernacularTitle:近红外荧光探针用于阿尔茨海默病标志物检测的研究进展
- Author:
Yiran GE
1
;
Jian YANG
;
Yuyan LI
;
Yungen XU
Author Information
1. 中国药科大学药物化学系
- Publication Type:Journal Article
- Keywords:
Alzheimer′s disease;
early diagnosis;
near-infrared fluorescence;
probes;
β-amyloid;
Tau protein;
reactive oxygen species
- From:
Journal of China Pharmaceutical University
2020;51(2):138-151
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer′s disease(AD)is a chronic neurodegenerative diseasecommonly seen in the elderlys. Several therapeutic drugs have failed in phase III clinical trials in recent years and there have been no efficient treatment for AD currently. Thus, there has been an urgent need for the effective methods of AD diagnosis at early stage. Developingnear-infrared fluorescentprobes for AD hallmarks detection has been a promising research field. In this review, we summarized a variety of near-infrared fluorescence(NIRF)probes reported in the past decade, which capable of detecting β-amyloid, Tau protein and reactive oxygen species, including their chemical strucutres、optical properties, in vitro and in vivo studies. Furthermore, we alsoraised some new directions for AD diagnosing. We believe that these new directions raised herein will benefit the future development of NIRF probes in the field of AD research.
