Research progress of glucagon-like peptide-1 and its analogues on oxidative stress
10.11665/j.issn.1000-5048.20200117
- VernacularTitle:胰高血糖素样肽-1及其类似物对细胞氧化应激的研究进展
- Author:
Lingling WU
1
;
Lidan SUN
Author Information
1. 嘉兴学院
- Publication Type:Journal Article
- Keywords:
glucagon-like peptide-1;
glucagon-like peptide-1 analogue;
oxidative stress
- From:
Journal of China Pharmaceutical University
2020;51(1):114-120
- CountryChina
- Language:Chinese
-
Abstract:
Glucagon-like peptide-1(GLP-1), a polypeptide secreted by small intestinal L cells, has various effects including increasing insulin synthesis and secretion, suppressing appetite, and delaying gastric emptying. In addition to glucose control, GLP-1 has multiple functions in a variety of tissues and organs. A number of studies have shown that GLP-1 receptor agonists could treat a variety of chronic diseases, including diabetes, through antioxidant mechanisms. Based on oxidative stress, this paper summarizes the current progress in the synthesis & metabolism, pancreatic and extracantral effects, anti-oxidation effects of diabetes and its complications, aging, and neurological diseases of GLP-1, with an attempt to provide theoretical reference to researches on related oxidative stress mechanisms and development of new drug.
