Comparison in treatment efficacy and safety between PD-1/PD-L1 inhibitor combined with chemotherapy and chemotherapy alone as first-line treatment for advanced NSCLC:AMeta-analysis
10.3872/j.issn.1007-385x.2020.03.015
- VernacularTitle:PD-1/PD-L1抑制剂联合化疗对比化疗一线治疗晚期非小细胞肺癌疗效 及安全性的Meta分析
- Author:
HUO Gengwei
1
;
SONG Ying
2
,
3
;
JIA Shasha
1
;
CHEN Weidong
1
Author Information
1. a. Department of Oncology
2. b. Department of Pharmacy, First People&rsquo
3. s Hospital of Jining City
- Publication Type:Journal Article
- Keywords:
non-small lung cancer (NSCLC);
PD-1/PD-L1 inhibitor;
chemotherapy;
programmed death-1(PD-1);
programmed deathligand 1 (PD-L1)
- From:
Chinese Journal of Cancer Biotherapy
2020;27(3):309-314
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To systematically evaluate the efficacy and safety of PD-1/PD-L1 inhibitor combined with chemotherapy as comparing with chemotherapy alone for the first-line treatment of advanced NSCLC (non-small lung cancer). Methods: RCTs (randomized controlled trials) on PD-1/PD-L1 inhibitor combined with chemotherapy compared with chemotherapy alone for the first-line treatment of advanced NSCLC were searched in the PubMed, Cochrane Library, EMbase, EBSCO, Chinese Biomedical Literature Database (CBM), Chinese Journal Full-text Database (CNKI), and Chinese Scientific Journal Full-text Database (VIP). RevMan 5.2 software was used for the Meta-analysis. Results: Six RCTs with 3 238 advanced NSCLC patients were included in this study. Meta-analysis showed that the combination therapy group was more effective than the chemotherapy alone group in OS (HR=0.86, 95%CI=0.79~ 0.94, P=0.0006) and PFS (HR=0.81, 95%CI=0.78~0.84, P<0.00001). The incidence of adverse reactions, such as thrombocytopenia of grade 1-5, vomiting, diarrhea, hypothyroidism, hyperthyroidism, rash, pneumonitis, colitis, hepatitis, dysgeusia, hepatitis of grade 3-5 and colitis, in combined treatment group were all higher than those in chemotherapy alone group, the differences were statistically significant (P<0.01 or P<0.05). Conclusions: Compared with chemotherapy alone, PD-1/PD-L1 inhibitor combined with chemotherapy can significantly improve the OS and PFS of patients with advanced NSCLC in the first-line treatment, while the overall incidence of adverse reactions is higher than chemotherapy.
- Full text:20200315.pdf
