Endoplasmic reticulum stress signaling pathway and its association with liver diseases
10.3969/j.issn.1001-5256.2020.02.051
- VernacularTitle:内质网应激的信号通路及其与肝脏疾病的关系
- Author:
Yao LI
1
;
Zhixin WANG
;
Hao WEN
Author Information
1. Graduate School of Qinghai University, Xining 810000, China
- Publication Type:Research Article
- Keywords:
liver diseases;
endoplasmic reticulum stress;
signal transduction;
apoptosis
- From:
Journal of Clinical Hepatology
2020;36(2):464-467
- CountryChina
- Language:Chinese
-
Abstract:
Endoplasmic reticulum stress (ERS) manifests as the aggregation of misfolded and unfolded proteins in the endoplasmic reticulum lumen and disorder of calcium balance and can activate the signaling pathways involved in unfolded protein response, endoplasmic reticulum overload reaction, and sterol regulatory cascade response. ERS can not only exert a protective effect by inducing the expression of endoplasmic reticulum molecular chaperones such as glucose-regulated protein 78 and glucose-regulated protein 94, but also induce cell apoptosis. At present, there is still no systematic understanding of ERS involvement in the development and progression of liver diseases. This article summarizes the research advances in ERS-related signaling pathways and related liver diseases and elaborates on the role of ERS-mediated cell apoptosis in liver diseases. The intervention of ERS signaling pathways may provide a reference for the research and treatment of liver diseases in the future.
