The immunoregulatory effect of tumor necrosis factor-alpha-induced protein 8-like 2 in different liver diseases
10.3969/j.issn.1001-5256.2020.02.050
- VernacularTitle:肿瘤坏死因子α诱导蛋白8样分子2在不同肝脏疾病中的免疫调控作用
- Author:
Shanshan WANG
1
;
Qingshan ZHANG
;
Suxian ZHAO
Author Information
1. Hebei Provincial Key Laboratory for Research on Pathogenesis of Chronic Liver Diseases and Liver Fibrosis, Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
- Publication Type:Research Article
- Keywords:
liver diseases;
TIPE2;
immunomodulation
- From:
Journal of Clinical Hepatology
2020;36(2):460-463
- CountryChina
- Language:Chinese
-
Abstract:
Tumor necrosis factor-alpha-induced protein 8-like 2 (TIPE2) can negatively regulate innate immunity and adaptive immunity and participate in the development and progression of various liver diseases, such as hepatitis, liver cirrhosis, and hepatocellular carcinoma, by affecting a variety of signaling pathways. This article summarizes the current research on the involvement of TIPE2 in the pathogenesis of different liver diseases and points out that TIPE2 may become a new target for the treatment of liver diseases.
