Role of silent information regulator 4 in the development and progression of liver diseases
10.3969/j.issn.1001-5256.2020.02.049
- VernacularTitle:沉默调节蛋白4在肝脏疾病发生发展中的作用
- Author:
Li XIE
1
;
Ningping ZHANG
;
Jian WU
Author Information
1. Department of Medical Microbiology and Parasitology, Fudan University School of Basic Medical Sciences, Shanghai 200032, China
- Publication Type:Research Article
- Keywords:
sirtuin-4;
hepatitis, viral, human;
non-alcoholic fatty liver disease;
liver cirrhosis;
carcinoma, hepatocellular
- From:
Journal of Clinical Hepatology
2020;36(2):456-459
- CountryChina
- Language:Chinese
-
Abstract:
Silent information regulators are a family of highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases and has seven members (Sirt1-7). Silent information regulator 4 (Sirt4), localized in the mitochondria, possesses the activity of deacetylase, ADP-ribosyltransferase, NAD+-dependent lipoamidase, and deacylase, participates in post-translational modification of mitochondrial proteins, and regulates multiple metabolic processes. Since metabolic dysfunction is closely associated with liver diseases, the role and regulatory mechanism of Sirt4 in liver diseases has attracted more and more attention. This article elaborates on the role of Sirt4 in viral hepatitis, nonalcoholic fatty liver disease, liver fibrosis, and hepatocellular carcinoma, in order to provide new perspectives for the prevention and treatment of these liver diseases.
