Programmed necrosis of macrophages plays an important role in liver immune response
10.3969/j.issn.1001-5256.2020.02.048
- VernacularTitle:巨噬细胞程序性坏死在肝脏免疫应答中的作用
- Author:
Simin ZHOU
1
;
Liping GUO
;
Jun ZHANG
Author Information
1. Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, China
- Publication Type:Research Article
- Keywords:
liver diseases;
macrophages;
apoptosis;
programmed necrosis;
immune system phenomena
- From:
Journal of Clinical Hepatology
2020;36(2):451-455
- CountryChina
- Language:Chinese
-
Abstract:
Liver macrophages are in a dynamic equilibrium of immune tolerance and immune response after continuous antigen stimulation. The immune response of liver macrophages to external antigen is closely associated with the immune homeostasis of the liver. This article reviews the association between the programmed necrosis pathway and the apoptotic pathway and elaborates on the important role of the activity of IKK complex in the interactive regulation of the programmed necrosis and apoptotic pathways. Further studies are needed to clarify the role of programmed necrosis in the response of liver macrophages to extrahepatic antigens.
