Research advances in cytokines associated with primary biliary cholangitis
10.3969/j.issn.1001-5256.2020.02.047
- VernacularTitle:原发性胆汁性胆管炎相关细胞因子的研究进展
- Author:
Zhiqin HUANG
1
;
Huifang HUANG
Author Information
1. The First Clinical Medical College of Shanxi Medical University, Taiyuan 030000, China
- Publication Type:Research Article
- Keywords:
primary biliary cholangitis;
cytokines;
signal transduction
- From:
Journal of Clinical Hepatology
2020;36(2):446-450
- CountryChina
- Language:Chinese
-
Abstract:
Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by nonsuppurative inflammation of the small- and medium-sized bile ducts in the liver. The pathogenesis of PBC remains unclear, and immunoregulation may play a critical role. As the important components of the immune system, cytokines may be involved in the pathogenesis of PBC. This article reviews related research advances in recent years, including the roles of pro-inflammatory cytokines (interleukin-12, interleukin-17, interleukin-9, interleukin-8, tumor necrosis factor-α, and interleukin-6), the anti-inflammatory cytokine interleukin-10, and their signaling pathways in PBC, so as to deepen the understanding of the pathogenesis of PBC and explore new treatment methods.
