Diagnostic value of CD4 cell count and IL-6/IL-10 ratio in combination for AIDS complicated with Pneumocystis pneumonia
10.3969/j.issn.1006-2483.2020.01.022
- VernacularTitle:CD4细胞计数和IL-6/IL-10比值联合对艾滋病合并肺孢子菌肺炎的诊断价值
- Author:
Qin XIANG
1
;
Pengcheng YE
2
;
Ronghui HE
1
;
Changyan ZHANG
1
;
Xiaoyan YU
1
Author Information
1. Department of Infection, Central Hospital of Nanchong, Sichuan 637000, China
2. Department of Gastrointestinal Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China
- Publication Type:Journal Article
- Keywords:
CD4 cells;
IL-6;
IL-10;
AIDS;
Pneumocystis pneumonia;
diagnosis
- From:
Journal of Public Health and Preventive Medicine
2020;31(1):95-99
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of CD4 cell count and IL-6/IL-10 ratio in combination for the diagnosis of AIDS complicated with Pneumocystis pneumonia. Methods A total of 100 AIDS patients with pneumocystis pneumonia admitted to the Nanchong Central Hospital from January 2018 to May 2019 were enrolled in the AIDS pneumonia group, 100 AIDS patients were enrolled in the AIDS group, and 100 healthy subjects were included in the control group. The number of CD4+T cells in serum was detected by flow cytometry, and the expression levels of IL-6 and IL-10 in serum were detected by enzyme-linked immunosorbent assay. The AUC of receiver operating characteristic curve (ROC) was used to analyze the CD4 cell count and the diagnostic significance of IL-6/IL-10 detection in AIDS with pneumocystis pneumonia. Results The number of CD4 cells in the serum of AIDS patients with Pneumocystis pneumonia was significantly lower than that of AIDS patients and healthy subjects (t=28.31, P<0.0001; t=36.90, P<0.0001), but the ratio of IL-6/IL-10 was higher than that of AIDS patients and healthy individuals (t=7.184, P<0.0001; t=19.03, P<0.0001). The sensitivity of CD4 cell count and IL-6/IL-10 ratio in the diagnosis of AIDS patients with Pneumocystis pneumonia was 92.00%, the specificity was 88.00%, and the accuracy was 89.33%. Conclusion The detection of CD4 cell count and IL-6/IL-10 ratio can be used as a potential marker for the diagnosis of AIDS with Pneumocystis pneumonia.
