Early adiposity rebound is associated with indices of obesity and metabolic risk in 5-year-old children: a birth cohort study in Ma’anshan
10.3969/j.issn.1006-2483.2020.01.009
- VernacularTitle:脂肪重积聚提前与5岁儿童肥胖和代谢各指标关联的队列研究
- Author:
Hui CAO
1
,
2
;
Shuangqin YAN
1
,
2
;
Liangliang XIE
1
,
2
;
Zhiling CAI
1
,
2
;
Guopeng GAO
1
,
2
;
Xiaogang YIN
1
,
2
;
Xianfa LU
1
,
2
;
Sumei WANG
1
,
2
;
Haiqin ZHU
1
,
2
;
Xiaoyan WU
3
,
4
,
5
;
Kui HUANG
3
,
4
,
5
;
Fangbiao TAO
3
,
4
,
5
Author Information
1. Maternal and Child Health Care Center of Maanshan, Ma'
2. anshan, Anhui 243000, China
3. Department of Maternal, Child, and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China
4. Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People'
5. s Republic of China/Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032,China
- Publication Type:Journal Article
- Keywords:
Adiposity rebound;
Overweight / obesity;
Body mass index (BMI);
Metabolic factors;
Children
- From:
Journal of Public Health and Preventive Medicine
2020;31(1):38-43
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the association between early adiposity rebound (AR) and indices of obesity and metabolic risk in 5-year-old children. Methods Based on Ma’anshan Birth Cohort Study (MABC), single live births born in Ma'anshan of Anhui province from October 2013 to April 2015 were followed for up to 5 years consecutively. As of August 2019, 720 children with continuous measurements (≥8 times) and metabolic indicators were obtained. Physical examination and laboratory tests were used to obtain information on the birth status, length/height, weight, waist circumference, body composition and metabolic indicators of children. The 2 test, F test, t-test, non-parametric test, general linear model and logistic regression model were used for statistical analysis. Results 43.5% of the children had AR≤4 years. After controlling for gender, it was found that earlier AR was associated with overweight/obesity (OR=2.71, 95%CI: 1.81~4.05), larger waist circumference (OR=1.88, 95%CI: 1.25~2.82), and body fat percentage ≥90th percentile (OR=2.09, 95%CI: 1.26~3.48). In the earlier AR group, the insulin resistance and metabolic score were higher, but the difference was not statistically significant. At 5 years of age, the prevalence of obesity and overweight was 6.0% and 12.8%, respectively. Children with overweight/obesity, larger waist circumference, higher waist-to-weight ratio and body fat percentage ≥ 90th percentile were associated with higher insulin resistance and metabolic score, and all the differences were statistically significant (all P<0.001). Conclusion Earlier AR increased the risk of overweight/obesity, larger waist circumference, and body fat percentage ≥90th percentile at age of 5 years. Each index of the commonly used measures of childhood obesity was closely related with insulin resistance and metabolic risk factors at 5 years old.
