Correlation analysis between P73 gene G4C14-to-A4T14 polymorphism and lung cancer risk in Guangdong population
10.3969/j.issn.1006-2483.2020.01.005
- VernacularTitle:广东省人群肺癌罹患风险与P73基因G4C14-to-A4T14多态性的相关性分析
- Author:
Suihua HUANG
1
,
2
;
Jinjun DONG
1
,
2
;
Qiong LUO
1
,
2
Author Information
1. Department of respiratory medicine,the Fifth Affiliated Hospital if Shenzhen University Shenzhen Bao'
2. an Central Hospital,Shenzhen,Guangdong 518000,China
- Publication Type:Journal Article
- Keywords:
P73 gene;
Polymorphism;
Lung cancer;
HRM
- From:
Journal of Public Health and Preventive Medicine
2020;31(1):21-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between P73 gene G4C14-to-A4T14 double nucleotide polymorphism and the risk of lung cancer in Guangdong population. Methods Genotype analysis of P73 gene polymorphism in peripheral blood of 642 patients with lung cancers (including 450 NSCLC patients and 192 SCLC patients) and 354 normal controls was performed with HRM method (high-resolution fusion curve). Results HRM genotyping results showed that the distribution of P73 genotypes in 450 NSCLC patients was as follows: GC/GC 280 (62.3%), GC/AT 155 (34.4%), and AT/AT 15 (3.3%). P73 genotypes in 192 SCLC patients were 118 GC/GC (61.5%), 67 GC/AT (34.9%) and 7 AT/AT (3.6%). The P73 genotypes of 354 normal controls were 192 GC/GC (53.1%), 136 GC/AT (38.5%), and 26 AT/AT (8.4%). AT/AT homozygous genotypes significantly reduced the risk of NSCLC (OR=0.393；95% CI:0.037-0.873；P=0.001) and SCLC (OR=0.428；95%CI:0.050-0.880；P<0.001) compared with non-carriers. Conclusion The results of the present study indicated that the polymorphism of P73 G4C14-A4T14 may be a modification factor for the susceptibility of lung cancer in Guangdong province, and the increased GC content in the P73 gene may increase the risk of lung cancer.
