The role of Sirtuins in the study of eye diseases
10.3980/j.issn.1672-5123.2020.5.19
- VernacularTitle:Sirtuins在眼科疾病中的研究进展
- Author:
Rong-Bin Liang
1
Author Information
1. Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaCo-first anthors: Rong-Bin Liang and Kang-Rui Wu.
- Publication Type:Review
- Keywords:
Sirtuins;
SIRT1;
retinal ganglion cells;
oxidative stress
- From:
International Eye Science
2020;20(5):831-833
- CountryChina
- Language:Chinese
-
Abstract:
In a variety of eye diseases, such as glaucoma, macular degeneration and other diseases, the occurrence of oxidative stress is very common, oxidative stress can cause cell damage and apoptosis. The Sirtuins family(histone class III deacetylases), as regulators of a variety of cells, is widely expressed in various organs of the human body. Homologous genes of sirtuins(SIRT1)are also widely expressed in the eyes, and their expression and activation can play an anti-oxidative stress role, prevent cell senescence and damage, and thus prevent the progression of disease. This paper discusses the mechanism and expression of Sirtuins family in glaucoma, senile macular degeneration, optic neuritis and senile cataract.
- Full text:202005019.pdf
