Research progress of extracellular high mobility group box 1 in common ophthalmic diseases
10.3980/j.issn.1672-5123.2020.5.15
- VernacularTitle:胞外HMGB1在常见眼科疾病中的研究进展
- Author:
Yong-Ying Zhou
1
,
2
,
3
,
4
Author Information
1. 1Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, China
2. 2Tianjin Eye Hospital
3. Tianjin Eye Institute
4. Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin 300020, China
- Publication Type:Review
- Keywords:
HMGB1;
inflammation;
immunology;
DAMP
- From:
International Eye Science
2020;20(5):813-817
- CountryChina
- Language:Chinese
-
Abstract:
High mobility group box 1(HMGB1), which belongs to a high mobility group box that known for high mobility in electrophoresis, has been researching most intensively. Recently, researches have revealed that extracellular HMGB1, as a damage-associated molecular pattern(DAMP), is involved in the pathophysiology of tissue damage repairin a variety of common ocular diseases, namely, dry eye, keratopathy, glaucoma, uveitis, diabetic retinopathy, and age-related macular degeneration, thereby negatively affecting the healing of the disease. Silencing the function of extracellular HMGB1 is expected to be a new way for these ophthalmic diseases. This thesis reviews the research progress of extracellular HMGB1 in common ophthalmic diseases.
- Full text:202005015.pdf
