Research progress of extracellular high mobility group box 1 in common ophthalmic diseases
10.3980/j.issn.1672-5123.2020.5.15
- VernacularTitle:胞外HMGB1在常见眼科疾病中的研究进展
- Author:
Yong-Ying Zhou
1
Author Information
1. 1Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, China; 2Tianjin Eye Hospital; Tianjin Eye Institute; Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin 300020, China
- Publication Type:Review
- Keywords:
HMGB1;
inflammation;
immunology;
DAMP
- From:
International Eye Science
2020;20(5):813-817
- CountryChina
- Language:Chinese
-
Abstract:
High mobility group box 1(HMGB1), which belongs to a high mobility group box that known for high mobility in electrophoresis, has been researching most intensively. Recently, researches have revealed that extracellular HMGB1, as a damage-associated molecular pattern(DAMP), is involved in the pathophysiology of tissue damage repairin a variety of common ocular diseases, namely, dry eye, keratopathy, glaucoma, uveitis, diabetic retinopathy, and age-related macular degeneration, thereby negatively affecting the healing of the disease. Silencing the function of extracellular HMGB1 is expected to be a new way for these ophthalmic diseases. This thesis reviews the research progress of extracellular HMGB1 in common ophthalmic diseases.
- Full text:202005015.pdf
