Medicinal chemistry strategies in seeking coronavirus inhibitors

VernacularTitle:冠状病毒抑制剂研究的药物化学策略
Author: Jing LI ^{1
,

2} ; Xiang-yi JIANG ^{1
,

2} ; Shu-jing XU ^{1
,

2} ; Qing-hua CUI ³ ; Rui-kun DU ³ ; Dong-wei KANG ^{1
,

2} ; Peng ZHAN ^{1
,

2} ; Li-jun RONG ⁴ ; Xin-yong LIU ^{1
,

2}
Author Information

1. Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
2. China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, Jinan 250012, China
3. College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
4. Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Publication Type:Research Article
Keywords: coronavirus; rug design; inhibitors; medicinal chemistry strategies
From: Acta Pharmaceutica Sinica 2020;55(4):537-553
CountryChina
Language:Chinese
Abstract: The epidemic caused by coronavirus poses a serious threat to human health, but there is no specific drug or vaccine for the treatment of this kind of virus infection. Herein, this article selects typical case studies in recent years and reviews the medicinal chemistry strategies of anti-SARS-CoV, MERS-CoV and other coronavirus drugs from the perspective of medicinal chemistry, and tries to provide some clues to current drug research againstSARS-CoV-2.