New advances in the discovery of anti-enterovirus-71 agents
10.16438/j.0513-4870.2019-0972
- VernacularTitle:抗肠病毒71型药物化学新进展
- Author:
Yu-cen TAO
1
;
Xia HAO
1
;
Xin-yong LIU
1
;
Peng ZHAN
1
Author Information
1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
- Publication Type:Research Article
- Keywords:
enterovirus71;
life cycle;
inhibitor;
replication cycle;
rug design
- From:
Acta Pharmaceutica Sinica
2020;55(4):744-753
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, enterovirus infection has become a frequent epidemic and developed into an important public health problem. For example, hand-foot-mouth disease has become a common infection among children in China. Hand-foot-mouth disease (HFMD) has been spreading globally since 1997, especially in the Asia-Pacific region. Enterovirus 71 (EV71) is one of the main pathogens causing HFMD. And now there is no drug available to treat EV71 infection. This review summarizes the research progress of anti-enterovirus-71 drugs from the perspective of medicinal chemistry.
