New progress in anti-norovirus drugs and vaccines

VernacularTitle:抗诺如病毒药物及其疫苗研究新进展
Author: Yue DONG ¹ ; Peng ZHAN ¹ ; Xin-yong LIU ¹
Author Information

1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
Publication Type:Research Article
Keywords: norovirus; acute gastroenteritis; rug target; inhibitor; vaccine
From: Acta Pharmaceutica Sinica 2020;55(4):640-651
CountryChina
Language:Chinese
Abstract: Norovirus (NoV) is the main pathogen causing the global acute gastroenteritis in humans and NoV infection has become an important public health problem that threatens human health. Because of the lack of appropriate animal models and in vitro cell culture models, the development of NoV biology and antiviral research has been restricted, and there is currently no effective antiviral drug or vaccine against NoV. In the past few years, considerable progress has been made toward the development of norovirus antivirals. This review selects the most representative research examples and provides an overview of recent advances in anti-norovirus drugs and vaccines.