Progress on the discovery and development of anti-zika virus agents
10.16438/j.0513-4870.2019-0748
- VernacularTitle:寨卡病毒抑制剂研究新进展
- Author:
Zhuo LI
1
;
Rui-fang JIA
1
;
Peng ZHAN
1
;
Xin-yong LIU
1
Author Information
1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
- Publication Type:Research Article
- Keywords:
Zika virus;
antiviral agent;
small molecule;
virus target;
host target;
rug design
- From:
Acta Pharmaceutica Sinica
2020;55(4):627-639
- CountryChina
- Language:Chinese
-
Abstract:
Zika virus (ZIKV) is a kind of mosquito-borne flavivirus. ZIKV infection initially shows mild symptoms on patients, but will lead to severe neurological complications (such as Guillain-Barré syndrome) in the end. Meanwhile, pregnant women are sensitive to ZIKV, since the viruses may cause microcephaly. In 2015, after the epidemic in Brazil, ZIKV draws the public attention around the world because of its increased virulence and rapid dissemination. However, there is no approved specific anti-ZIKV drugs at present. This review summarizes progress on anti-zika virus drug research and provides prospects in this field.
