Case Reports of Two Patients with Pregnancy-associated Breast Cancer and Related Literature Review
- VernacularTitle:2例妊娠相关乳腺癌患者的病例报道及相关文献复习
- Author:
Siyao JIN
1
,
2
;
Zhigang ZHAO
1
;
Jiping HUO
1
Author Information
1. Dept. of Pharmacy，Beijing Tiantan Hospital，Capital Medical University，Beijing 100160，China
2. Dept. of Clinical Pharmacology，College of Pharmaceutical Sciences，Capital Medical Universi ty，Beijing 100069，China
- Publication Type:Journal Article
- Keywords:
Pregnancy-associated breast cancer;
Case report;
Literature review;
Neoadjuvant chemotherapy;
Chemotherapy-
- From:
China Pharmacy
2020;31(8):989-996
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To provide reference for the early diagnosis and selection of treatment regimens of pregnancy- associated breast cancer （PABC）. METHODS ：The disease characteristics ，treatment process and prognosis of 2 cases of PABC were analyzed in our hospital. The relevant literature published from Jan. 1986 to Apr. 2019 in PubMed database was retrieved. The case reports that the title ，keywords or abstracts involved “Breast cancer and pregnancy ”“Pregnancy-associated breast cancer ” “Breast cancer during pregnancy ”“Breast carcinoma during pregnancy ”“Case reports ”were included. Cases which didn ’t meet the definition of PABC were excluded. The general information ，tumor clinical characteristics ，drug treatment plan ，maternal/fetal prognosis and other information of patients were extracted for summary and descriptive statistical analysis. RESULTS & CONCLUSIONS：Two patients were both diagnosed during lactation. The prognosis was good after neoadjuvant chemotherapy and surgical resection. A total of 36 case reports were obtained through literature search and screening ，as well asclinical data of 45 patients（39 diagnosed during pregnancy and 6 diagnosed during lactation ）.Neoadjuvant chemotherapy AC regimen （doxorubicin+ cyclophosphamide）was used in 35.0％（14/40）of cases after excluding the cases without relevant information ；elective caesarean section was performed in 59.5％（22/37）of cases ，37.8％（14/37）of cases were delivered ，and 1 case chose to terminate pregnancy；survival rate of patients was 80.8％（21/26），and the average weight of newborns was 2 407 g（1 015-3 830 g）. Six patients each received taxanes during pregnancy and 9 patients during postpartum. The determination of chemotherapy for PABC should comprehensively consider a variety of factors. It is necessary to comprehensively weigh the benefit risks of the mother and child，try to avoid chemotherapy in early pregnancy ，and especially consider the impact of chemotherapy on the fetus. The chemotherapy regimen is still dominated by anthracyclines. Based on this ，an individualized regimen is formulated and close monitoring should be performed when using paclitaxel.
