Clinical Observation of Recombinant Human Interferon Gel Combined with Baofukang Suppository in the Treat- ment of Cervical High-risk HPV Infection
- VernacularTitle:重组人干扰素凝胶联合保妇康栓治疗宫颈高危型HPV感染的临床观察
- Author:
Xiaoyu SU
1
;
Liping MENG
2
;
Congcong ZOU
2
;
Jufeng ZHOU
3
;
Fang WANG
4
;
Manling CHEN
1
Author Information
1. Dept. of Gynaecology,the First Affiliated Hospital of Hainan Medical University,Haikou 570102,China
2. Nursing Department,the First Affiliated Hospital of Hainan Medical University,Haikou 570102,China
3. Nutritional Department,the First Affiliated Hospital of Hainan Medical University,Haikou 570102,China
4. Dept. of Gynaecology,Haikou Municipal People’s Hospital,Haikou 570208,China
- Publication Type:Journal Article
- Keywords:
Recombinant human interferon;
Baofukang suppository;
Cervix;
High-risk HPV;
Infection;
Clinical observation
- From:
China Pharmacy
2020;31(8):984-988
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To inv estigate therapeutic efficacy and safety of recombinant human interferon gel combined with Baofukang suppository in the treatment of cervical high-risk human papillomavirus (HPV)infection. METHODS :Totally 259 patients with persistent high-risk HPV infection diagnosed and treated in gynecology department of the First Affiliated Hospital of Hainan Medical University from Aug. 2017 to Sept. 2019 were selected and divided into interferon group (n=82),Baofukang suppository group (n=86)and combination group (n=91)according to random number table. The patients in interferon group and Baofukang suppository group were given Recombinant human interferon α2b gel 1 g, qd or Baofukang suppository 1 capsule,qd; the patients in combination group were given Recombinant human interferon α2b gel and Baofukang suppository 1 capsule,qd;for 3 months. Then the clinical efficacy ,negative time of HPV ,duration of abnormal secretion ,LCT test results ,cervical inflammation score ,HPV relative light unit/critical value (RLU/CO)and the incidence of ADR were recorded. RESULTS :The total effective rate of combination group was significantly higher than that of interferon group and Baofukang suppository group , the negative time of HPV and duration of abnormal secretion in combination group were significantly shorter than interferon group and Baofukang suppository group (P<0.05). Before treatment ,the normal rate of LCT of 3 groups were 0,and there was no statistical significance in cervical inflammation score and HPV RLU/CO among 3 groups(P>0.05). After treatment ,normal rate of LCT was increased in 3 groups,compared with before treatment (P<0.05),and normal rate of LCT in combination group was significantly higher than interferon group and Baofukang suppository group. The cervical inflammation score and HPV RLU/CO were significantly lower than before treatment ,and the combination group was significantly lower than interferon group and Baofukang suppository group (P<0.05). There was no statistical significance in above indicatora after treatment betwent interferon group and Baofukang suppository group and the incidence of ADR among 3 groups during medication (P>0.05). CONCLUSIONS:The application of recombinant human interferon gel combined with Baofukang suppository is effective and safe way in the treatment of cervical high-risk HPV infection.