Depressed Inflammatory Response to Repeated Angioplasty in Unstable Angina Patients with an In-Stent Restenosis.
- Author:
Sang Jin HAN
1
;
Young Cheoul DOO
;
Goo Yung CHO
;
Kyung Soon HONG
;
Kyoo Rok HAN
;
Nam Ho LEE
;
Dong Jin OH
;
Kyu Hyung RYU
;
Chong Yun RIM
;
Kwang Hahk LEE
;
Yung LEE
Author Information
- Publication Type:Original Article
- Keywords: C-reactive protein; Coronary restenosis; Stents; Angioplasty
- MeSH: Angina, Unstable*; Angioplasty*; Angioplasty, Balloon, Coronary; C-Reactive Protein; Coronary Restenosis; Humans; Inflammation; Male; Stents
- From:Korean Circulation Journal 2004;34(1):41-46
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Inflammation plays a key role in the pathogenesis of an in-stent restenosis because it promotes neointimal proliferation. This study was performed to determine responses of the C-reactive protein (CRP) in unstable angina patients with an in-stent restenosis undergoing repeated percutaneous transluminal coronary angioplasty (re-PTCA). METHODS: The study subjects (unstable angina) were classified into 2 groups:Group A (n=30, 15 men, mean age 62 years) had a re-PTCA for an in-stent restenosis lesion and Group B (n=60, 33 men, mean age 63 years) underwent a stent implantation for a de novo lesion. RESULTS: The baseline CRP levels in group A were significantly lower than in group B, as well as 6 and 24 hours after intervention. Twenty four hours after intervention, the CRP levels increased (>4 mg/L) in 3 out of 30 patients (10%) of group A but increased in 32 out of 60 patients (53%) in group B (p<0.001). The differences in the CRP levels between the baseline and 24 hours after intervention were significantly lower in group A than in group B (0.8 and 2.15 mg/L, respectively, p<0.001). In group B, the serum CRP levels 24 hours after intervention were significantly higher than the baseline levels (p<0.05), but not in group A. CONCLUSION: The CRP expression level is significantly lower in unstable angina patients undergoing a re-PTCA for an in-stent restenosis than those undergoing a stent implantation for a de novo lesion.
