Molecular Imaging for Theranostics in Gastroenterology: One Stone to Kill Two Birds.
- Author:
Kwang Hyun KO
1
;
Chang Il KOWN
;
Jong Min PARK
;
Hoo Geun LEE
;
Na Young HAN
;
Ki Baik HAHM
Author Information
- Publication Type:Review
- Keywords: Molecular imaging; Spectrum analysis, Raman; Imaging mass spectroscopy; Theranostics; Individualized medicine
- MeSH: Biochemistry; Birds*; Diagnosis; Endoscopy; Gastroenterology*; Mass Spectrometry; Molecular Biology; Molecular Imaging*; Narrow Band Imaging; Optical Imaging; Spectrum Analysis, Raman; Biomarkers; Precision Medicine
- From:Clinical Endoscopy 2014;47(5):383-388
- CountryRepublic of Korea
- Language:English
- Abstract: Molecular imaging in gastroenterology has become more feasible with recent advances in imaging technology, molecular genetics, and next-generation biochemistry, in addition to advances in endoscopic imaging techniques including magnified high-resolution endoscopy, narrow band imaging or autofluorescence imaging, flexible spectral imaging color enhancement, and confocal laser endomicroscopy. These developments have the potential to serve as "red flag" techniques enabling the earlier and accurate detection of mucosal abnormalities (such as precancerous lesions) beyond biomarkers, virtual histology of detected lesions, and molecular targeted therapy-the strategy of "one stone to kill two or three birds"; however, more effort should be done to be "blue ocean" benefit. This review deals with the introduction of Raman spectroscopy endoscopy, imaging mass spectroscopy, and nanomolecule development for theranostics. Imaging of molecular pathological changes in cells/tissues/organs might open the "royal road" to either convincing diagnosis of diseases that otherwise would only be detected in the advanced stages or novel therapeutic methods targeted to personalized medicine.
