Drug Eruption & Liver Damage due to Diaminodiphenyl - Sulfone (DDS): Report of a case.
- Author:
Yoon Kee PARK
;
Won Ho LEE
;
Mi Ji Hee TAK
- Publication Type:Original Article
- MeSH:
Adolescent;
Alanine Transaminase;
Anemia;
Bilirubin;
Dermatitis, Exfoliative;
Drug Eruptions*;
Eating;
Erythema Multiforme;
Exanthema;
Female;
Fever;
Hepatitis;
Humans;
Korea;
Liver Function Tests;
Liver*;
Methemoglobinemia;
Neuritis;
Prescriptions;
Psychotic Disorders;
Sclera;
Skin Diseases;
Stevens-Johnson Syndrome
- From:Korean Journal of Dermatology
1980;18(3):241-245
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of drug eruption and liver damage due to diaminodiphenyl suIfone(DDS) ingestion in a 17-year-old female. This patient had taken DDS for 20 days, 100mg-200mg daily to treat an unknown skin disease. Thereafter, she had generalized erythematous eruption on whole body, icteric sclera and fever. Liver function test showed abnormality (SGOT 514 unit, SGPT 710 unit, alkarine phosphotase 4. 3 B.U., total biIirubin 7. Oml/dl, direct bilirubin 4. 8mg/dl). The adverse reactiions to DDS are gastrointestinal intolerance, hemolytic, anemia, methemoglobinemia, agranulocytoais, hepatitis, neuritis, psychosis and a skin rash described as a fixed drug eruption, erythema multiforme, exfoliative dermatitis and toxic epidermal necrolysis. In Korea, DDS has been used for the treatment of skin diseases of various types for a long time without prescription, especially in rural areas. This trend is a significant sociomediical problem in Korea.
