Effects of 12week exercise intervention on endothelium function among overweight and obese children
10.16835/j.cnki.1000-9817.2019.01.007
- VernacularTitle:运动干预12周对超重/肥胖儿童内皮细胞功能的影响
- Author:
GUI Yongling
1
Author Information
1. Zhengzhou Shengda University of Economics Business
- Publication Type:Journal Article
- Keywords:
Overweight;
Obesity;
Intervention studies;
Health promotion;
Child;
Endothelial cells
- From:
Chinese Journal of School Health
2019;40(1):26-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of 12week exercise prescription intervention on endothelium function among overweight and obese children, and to provide an effective way of improving the cardiovascular health among overweight and obese children.
Methods:A total of 69 overweight and obese children were randomly divided into control group(35) and exercise group(34). Subjects in control group only participated in physical activity organized by school and those in exercise group performed 12week (3 times/week) exercise prescription intervention (aerobic exercise combined with resistance training) based on control group. Expression (demonstrated by positive cell percentage) of peripheral blood CD34+ (cell surface marker of hematopoietic stem cells), CD133+ (cell surface marker of hematopoietic progenitor cells) and CD34+CD133+ (considered as endothelial progenitor cells) were determined by flow cytometry, carotid intimamedia thickness (cIMT) was measured by Bmode ultrasound, vascular endothelium function demonstrated by reactive hyperemia index (RHI) using endothelial functionperipheral arterial tonometry technique before and after experiment respectively.
Results:After experiment, expression of CD34+ (pre: 0.04±0.01%, post: 0.087±0.044%), CD133+ (pre: 0.077±0.030%, post: 0.192±0.076%) and CD34+CD133+ (pre: 0.062±0.011%, post: 0.110±0.034%) upregulated (P<0.01), RHI increased (pre: 0.043±0.011%, post: 0.087±0.044%，P=0.018) while cIMT decreased (pre: 0.043±0.011%, post: 0.087±0.044%，P<0.05) in exercise group, whereas students in control group showed no significant difference in these indices(P>0.05).
Conclusion:Twelveweek exercise intervention improved endothelium function via mobilizing endothelial progenitor cells in overweight and obese children.
