Association between mitochondria and hepatocellular injury
10.3969/j.issn.1001-5256.2020.03.048
- VernacularTitle:线粒体与肝细胞损伤的关系
- Author:
Hailiang WEI
1
;
Mingming SI
;
Hui GUO
Author Information
1. First Department of General Surgery, The Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712000, China
- Publication Type:Research Article
- Keywords:
mitochondria, liver;
liver diseases;
hepatocyte injury
- From:
Journal of Clinical Hepatology
2020;36(3):687-689
- CountryChina
- Language:Chinese
-
Abstract:
The mitochondria in liver tissue not only provides energy for substance metabolism in hepatocytes, but also participates in hepatocellular injury and even apoptosis. It also plays an important role in several pathological processes closely associated with hepatocellular injury and apoptosis, such as hepatitis, hepatic fibrosis, precancerous lesion, and liver cancer. This article elaborates on the association between mitochondria and hepatocellular injury from the following aspects: the important role of the change in mitochondrial membrane permeability in hepatocellular injury, hepatocellular injury accelerated by ATP synthesis disorder and consumption, and the association of abnormal Ca2+ homeostasis in hepatocellular mitochondria with hepatocellular injury, in order to provide a theoretical basis for mitochondria-targeted prevention and treatment of chronic liver diseases due to hepatocellular injury.
