Mechanism of action of chemotherapy drugs in promoting liver injury
10.3969/j.issn.1001-5256.2020.03.045
- VernacularTitle:化疗药物致肝损伤的作用机制
- Author:
Kai FANG
1
;
Jian XU
;
K XU
Author Information
1. Central Laboratory, Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200000, China
- Publication Type:Research Article
- Keywords:
drug-induced liver injury;
chemistry, pharmaceutical;
therapeutics
- From:
Journal of Clinical Hepatology
2020;36(3):677-679
- CountryChina
- Language:Chinese
-
Abstract:
Drugs are an important cause of liver injury, and according to statistics, about 1100 drugs may induce liver injury. Due to the difficulty in differential diagnosis, drug-related liver injury is still misjudged. As different drugs have different mechanisms of action in inducing liver injury and may cause different degrees of liver injury, targeted countermeasures should be adopted. There are fewer systematic reviews of liver injury caused by chemotherapy drugs. This article mainly introduces the hepatotoxic mechanisms of various chemotherapy drugs, elaborates on the degree of hepatotoxicity caused by chemotherapy drugs, summarizes the clinical manifestations of liver injury caused by chemotherapy drugs, and gives recommendations to clinical treatment.
