The role of gut microbiota in the pathogenesis of portal hypertension
10.3969/j.issn.1001-5256.2020.03.044
- VernacularTitle:肠道菌群在门静脉高压发病机制中的作用
- Author:
Qun ZHANG
1
;
Xianbo WANG
Author Information
1. Department of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
- Publication Type:Research Article
- Keywords:
gut microbiota;
portal hypertension;
liver cirrhosis;
gut-liver axis
- From:
Journal of Clinical Hepatology
2020;36(3):673-676
- CountryChina
- Language:Chinese
-
Abstract:
Gut microbiota is the largest collection of commensal micro-organisms in the human body. Since the liver has unique anatomical location and vascular system, it is easily exposed to gut microbiota and their metabolites. Under normal conditions, the barrier function of the intestinal epithelium and the cleaning and detoxification function of the liver can prevent microorganisms or their products from entering the liver and systemic circulation. However, when the intestinal barrier function is damaged, a large number of bacterial products may enter the liver and systemic circulation and stimulate the body’s immune and inflammatory responses, and such perturbations become prominent in liver cirrhosis and may increase the risk of clinically significant portal hypertension. This article summarizes the role of gut microbiota in the pathogenesis of portal hypertension and provides ideas for clinical treatment.
