Research advances in drug-induced liver injury
10.3969/j.issn.1001-5256.2020.03.006
- VernacularTitle:药物性肝损伤的研究进展
- Author:
Xue YANG
1
;
Rongfang TU
;
Jinhui YANG
Author Information
1. Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650000, China)
- Publication Type:Research Article
- Keywords:
drug-induced liver injury;
pathological conditions, signs and symptoms;
risk factors;
diagnosis
- From:
Journal of Clinical Hepatology
2020;36(3):509-513
- CountryChina
- Language:Chinese
-
Abstract:
Drug-induced liver injury (DILI) has a complex pathogenesis and obvious individual difference. Early diagnosis and treatment of DILI may achieve good prognosis, but due to a lack of specific clinical symptoms, most cases cannot be identified in the early stage. If no timely treatment is given, DILI may progress to irreversible liver failure with a high mortality rate, and there are no effective therapies for advanced DILI except liver transplantation. Therefore, early diagnosis and treatment are of great importance for patients with DILI. This article summarizes the recent research advances in DILI, including suspected drugs, risk factors, pathogenesis, pathological features, clinical types and manifestations, diagnostic criteria and evaluation, and network database, in order to provide a basis for early diagnosis, clinical typing, treatment guidance, and prognostic evaluation of DILI.
