STAT3: A key molecule in the progression of liver cancer mediated by chronic inflammation
10.3969/j.issn.1001-5256.2020.04.054
- VernacularTitle:STAT3: 慢性炎症介导肝癌进程的关键分子
- Author:
Jinping YIN
1
;
Zichen YUE
;
Shaoyuan ZHUO
Author Information
1. School of Basic Medical Sciences, Guangxi University of Chinese Medicine, Nanning 530200, China
- Publication Type:Research Article
- Keywords:
liver neoplasms;
STAT3 transcription factor;
inflammation
- From:
Journal of Clinical Hepatology
2020;36(4):948-952
- CountryChina
- Language:Chinese
-
Abstract:
STAT3, a member of the signal transducer and activator of transcription family, is abnormally activated in chronic inflammation-related tumors including liver cancer. As a key signal molecule in the microenvironment of liver cancer and inflammation, STAT3 not only participates in the inflammation-cancer transformation during the development of liver cancer, but also promotes the proliferation, invasion, and metastasis of hepatoma cells through many ways, and therefore, it may be a potential target for the treatment of liver cancer. This article reviews the recent advances in the association between STAT3 and liver cancer.
