Role of hepatic macrophages in the development and progression of primary biliary cholangitis
10.3969/j.issn.1001-5256.2020.04.051
- VernacularTitle:肝巨噬细胞在原发性胆汁性胆管炎发生发展中的作用
- Author:
Wenxia YANG
1
;
Yingmei TANG
Author Information
1. Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650000, China
- Publication Type:Research Article
- Keywords:
primary biliary cholangitis;
macrophages;
Toll-like receptors
- From:
Journal of Clinical Hepatology
2020;36(4):936-939
- CountryChina
- Language:Chinese
-
Abstract:
Primary biliary cholangitis(PBC) is a chronic autoimmune liver disease characterized by cholestasis and has unknown etiology. Its specific pathogenesis remains unclear, but hepatic macrophages are one of the key aspects of the immune and inflammatory response of PBC and the injury of biliary epithelial cells. Hepatic macrophages are classified into resident Kupffer cells and monocyte-derived macrophages according to their source, and these cells play an important role in the development and progression of PBC. This article reviews the role of hepatic macrophages in the development and progression of PBC.
