The role of butyrate in the development and progression of nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2020.04.046
- VernacularTitle:丁酸在非酒精性脂肪性肝病发生发展中的作用
- Author:
Wencheng DANG
1
;
Fengcheng DENG
;
Zhaolong LI
Author Information
1. Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, China
- Publication Type:Research Article
- Keywords:
non-alcoholic fatty liver disease;
butyric acids;
gastrointestinal microbiome
- From:
Journal of Clinical Hepatology
2020;36(4):915-918
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis caused by nonalcoholic factors, and its pathogenesis, progression, treatment, and prevention have attracted more and more attention. At present, an increasing number of studies have been conducted on the association of intestinal microecology with various metabolic diseases such as obesity, diabetes, and cardiovascular diseases. Recent studies have found that butyrate, a metabolite of intestinal flora, is closely associated with NAFLD and can affect the development and progression of NAFLD through various mechanisms, such as alleviating inflammatory response, inhibiting insulin resistance, and reducing oxidative stress of liver mitochondria. Exploration of the association between butyrate and NAFLD is expected to provide a new approach for the prevention and treatment of NAFLD.
