Hepatitis B virus-mediated interaction between hepatic stellate cells and innate immune cells
10.3969/j.issn.1001-5256.2020.04.040
- VernacularTitle:HBV介导的肝星状细胞和天然免疫细胞的相互作用
- Author:
Miaomiao YANG
1
;
Zhihui WU
;
Zhengkun TU
Author Information
1. Research Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130021, China)
- Publication Type:Research Article
- Keywords:
hepatitis B virus;
liver cirrhosis;
hepatic stellate cells;
mononuclear phagocyte system;
NK cells
- From:
Journal of Clinical Hepatology
2020;36(4):891-894
- CountryChina
- Language:Chinese
-
Abstract:
Liver nonparenchymal cells play an important role in hepatitis B virus (HBV)-related liver diseases, and the activation of hepatic stellate cells (HSCs) and their interactions with intrahepatic cells are the main cause of liver fibrosis. This article mainly introduces HBV-induced liver inflammation and the interaction between innate immune cells and HSCs and briefly describes the role of monocytes/macrophages and natural killer cells in the activation and killing of HSCs and the immunomodulatory effect of HSCs in the presence of HBV.
