Application of probe-based confocal laser endomicroscopy in diagnosis of gastric carcinoma and precancerous lesions.
- Author:
Panpan MA
1
;
Lijun CAI
1
;
Bin LYU
1
;
Min YUE
2
Author Information
1. Department of Gastroenterology, the First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Key Laboratory for Pathophysiological Research on Digestive System Diseases, Hangzhou 310006, China.
2. Department of Gastroenterology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
- Publication Type:Journal Article
- MeSH:
Carcinoma;
diagnostic imaging;
Endoscopy, Gastrointestinal;
Humans;
Metaplasia;
Microscopy, Confocal;
Precancerous Conditions;
diagnostic imaging;
Sensitivity and Specificity;
Stomach;
diagnostic imaging;
pathology;
Stomach Neoplasms;
diagnostic imaging
- From:
Journal of Zhejiang University. Medical sciences
2019;48(5):504-510
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To assess the application of probe-based confocal laser endomicroscopy (pCLE) in diagnosis of gastric carcinoma and precancerous lesions.
METHODS:Patients underwent pCLE in the First Affiliated Hospital of Zhejiang University School of Medicine during December 2013 and November 2014 and in the First Affiliated Hospital of Zhejiang Chinese Medical University during January 2014 and December 2017 were enrolled. The consistency between pCLE diagnosis and pathological diagnosis of gastric lesions, including atrophic gastritis, gastric intestinal metaplasia, low-grade intraepithelial neoplasia and high-grade intraepithelial neoplasia (including gastric carcinoma) was analyzed.
RESULTS:Totally 154 gastric lesions from 119 patients were detected by pCLE. Using pathological diagnosis as gold standard, the sensitivity, specificity, coincidence rate and κ value of pCLE diagnosis for atrophic gastritis were 94.34%, 91.09%, 92.21%and 0.83; those indicators for gastric intestinal metaplasia were 84.47%, 92.16%, 87.01% and 0.72. The coincidence rate and κ value of pCLE diagnosis of complete gastric intestinal metaplasia were 0.75 and 0.49; for incomplete gastric intestinal metaplasia were 0.79 and 0.48, respectively. The sensitivity, specificity, coincidence rate and κ value of pCLE diagnosis for low-grade intraepithelial neoplasia were 85.29%, 87.50%, 87.01%and 0.66; those for high-grade intraepithelial neoplasia (including gastric carcinoma) were 95.83%, 97.17%, 96.75%and 0.92.
CONCLUSIONS:pCLE can be used for diagnosis of gastric carcinoma and pericancerous lesions and also for typing of gastric intestinal metaplasia.
