Autophagy regulates the function of vascular smooth muscle cells in the formation and rupture of intracranial aneurysms.
- Author:
Junhao ZHANG
1
;
Jinghua JIN
1
;
Wei YANG
1
Author Information
1. Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Autophagy;
Humans;
Intracranial Aneurysm;
pathology;
Muscle, Smooth, Vascular;
cytology;
Myocytes, Smooth Muscle;
cytology
- From:
Journal of Zhejiang University. Medical sciences
2019;48(5):552-559
- CountryChina
- Language:Chinese
-
Abstract:
Vascular smooth muscle cells (VSMC) are the main cellular component of vessel wall. The changes of VSMC functions including phenotypic transformation and apoptosis play a critical role in the pathogenesis of intracranial aneurysm (IA). Autophagy can participate in the regulation of vascular function by regulating cell function. In the initial stage of IA, the activation of autophagy can accelerate the phenotypic transformation of VSMC and inhibit VSMC apoptosis. With the progress of IA, the relationship between autophagy and apoptosis changes from antagonism to synergy or promotion, and a large number of apoptotic VSMC lead to the rupture of IA. In this review, we describe the role of autophagy regulating the function of VSMC in the occurrence, development and rupture of IA, for further understanding the pathogenesis of IA and finding molecular targets to prevent the formation and rupture of IA.
