Research progress on uniparental disomy in cancer.
- Author:
Dianyu CHEN
1
;
Ming QI
1
Author Information
1. Department of Genetics, Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Genomic Imprinting;
Humans;
Neoplasms;
genetics;
Research;
trends;
Uniparental Disomy
- From:
Journal of Zhejiang University. Medical sciences
2019;48(5):560-566
- CountryChina
- Language:Chinese
-
Abstract:
Uniparental disomy (UPD) refers to a chromosome defect that an individual's homologous chromosome or segments are inherited from one parent. UPD can cause either aberrant patterns of genomic imprinting or homozygosity of mutations, leading to various diseases, including cancer. The mechanisms of UPD formation are diverse but largely due to the incorrect chromosome separation during cell division. UPD does not alter the number of gene copies, thus is difficult to be detected by conventional cytogenetic techniques effectively. Assisted by the new techniques such as single nucleotide polymorphism arrays, more and more UPD-related cases have been reported recently. UPD events are non-randomly distributed across cancer types, which play important role in the occurrence, development and metastasis of cancer. Here we review the research progress on the formation mechanisms, detection methods, the involved chromosomal regions and genes, and clinical significance of UPD; and also discuss the directions for future studies in this field.
