Advances in researches on mechanism of macrophage migration inhibitory factor regulating parasite-host immune interaction
10.16250/j.32.1374.2018229
- VernacularTitle:巨噬细胞迁移抑制因子调节寄生虫与宿主免疫系统相互作用机制的研究进展
- Author:
Lin HUANG
1
,
2
;
Yuan-Fen MA
3
;
Ling-Jun WANG
1
;
Ming-Hui ZHENG
1
;
Hui LIU
1
Author Information
1. Department of Parasitology, Zunyi Medical College, Zunyi 563100, China
2. Qiannan Medical College for Nationalities, China
3. Department of Morphology, Zunyi Medical College, China
- Publication Type:Journal Article
- Keywords:
Macrophage migration inhibitory factor (MIF);
Parasite;
Host;
Immune response;
Interaction
- From:
Chinese Journal of Schistosomiasis Control
2019;31(4):446-449
- CountryChina
- Language:Chinese
-
Abstract:
Macrophage migration inhibitory factor (MIF), a type of pleiotropic immunoregulatory cytokine with a specific structure, participates in the regulation of host cell growth and migration and immune responses. Following parasitic infections, hosts may produce MIF and then participate in the parasite-host interactions. In addition, parasites may secrete parasite-derived MIF, and they jointly participate in parasite-host interactions. This paper reviews the regulation of MIF gene expression following parasitic infections, the role of MIF in parasite-host immune system interactions, and important signaling pathways of MIF-mediated immune responses.
