Changes of inflammatory factors after hepatic cystic echinococcosis surgery and intervention of ulinastatin in Qinghai area
10.16250/j.32.1374.2018089
- VernacularTitle:青海地区肝细粒棘球蚴病患者术后炎性因子变化及乌司他丁干预作用的临床研究
- Author:
Qing-Shan TIAN
1
;
Ji-De A
1
;
Xiang-Qian WANG
1
;
Shun-Yun ZHAO
1
;
Zi-Xuan GONG
1
;
Jin-Yu YANG
1
;
Chang-Chun QIN
1
Author Information
1. Department of General Surgery, Qinghai Provincial People’s Hospital, Xining 810007, China
- Publication Type:Journal Article
- Keywords:
Hepatic cystic echinococcosis;
Ulinastatin;
Inflammatory factor;
Qinghai area
- From:
Chinese Journal of Schistosomiasis Control
2018;30(6):667-670
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of inflammatory factors after the hepatic cystic echinococcosis surgery and explore the intervention effect of ulinastatin on postoperative inflammatory factors. Methods Sixty patients with hepatic cystic echinococcosis were selected and randomly divided into a control group and ulinastatin intervention group according to whether or not use ulinastatin. The peripheral venous blood was extracted in all the patients and the levels of IL-6, IL-8, IL-9, and IL-10 were detected by the ELISA method on the day before operation, 1 day, 3 days, 5 days and 7 days after operation, respectively. The data was statistical analyzed to detect the relationships between/among the inflammatory factors mentioned above and ulina-statin and time. Results The variation of the levels of IL-6, IL-8, IL-9, and IL-10 were changed by the intervention of ulina-statin at different time. The differences of the levels of IL-6, IL-8, IL-9, and IL-10 between the ulinastatin intervention group and the control group were not significant on the day before operation, 1 day and 3 days after operation (t = -1.15 to 1.82, all P > 0.05), but the levels of IL-6, IL-8, IL-9, and IL-10 of the ulinastatin intervention group were significantly lower than those of the control group and there were statistically significant differences 5 days and 7 days after the operation (t = 3.22 and 23.51, both P<0.05) . Conclusion Ulinastatin has a good effect in inhibiting the inflammatory factors and can protect and repair the postoperative hepatic injury as well in patients with hepatic cystic echinococcosis.
